Dr Katarzyna Szymanska

Katarzyna Szymanska

Post-doctoral Research Fellow

Leeds Institute of Medical Research at St James’s
University of Leeds
LocationUnited Kingdom

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Research Interests

primary cilia, MKS1, kidney organoids, polycystic kidney, ubiquitination

I'm interested in genetics and cell biology of ciliopathies, in particular Meckel-Gruber and Joubert syndromes. Although many causative genes for these conditions were identified we are still hoping to complete the set. I look into function of the identified genes/proteins in primary cilia function and sturcture, particularly its subcompatment - the transition zone. I aim to identify new transition zone components using high-content high-throughput screening. I'm also interested in the role of post-translational modifications of ciliary proteins, in particular ubiquitination. I use CRISPR-Cas9 to engineer MKS1 patient variants into iPSCs and differentiate them into kidney organoids to investigate the molecular mechanisms driving ciliopathy pathology.