Close

A note on cookies

We use cookies to improve your experience of our website. If you want to find out more see our Privacy Policy

Menu
People menu

Ms Isabella Collins

Department Kennedy Institute, Medical sciences, NDORMS
Location University of Oxford
Email  isabella.collins@lincoln.ox.ac.uk

Research Keywords

Matrix, Cartilage, Primary cilia, Endocytosis, Osteoarthritis

Research Interests

My project will investigate a putative axis of matrix regulation between the chondrocyte ciliome and/or periciliary architecture including the ciliary pocket, and matrix remodelling in osteoarthritis. Specifically the project has 4 key questions. 

1. How is the ciliome altered in clinical OA - what is the OA genomic signature that relates to cilia?

2. How is chondrocyte/ciliary pocket orientation disturbed in OA?   

3. How do IFTs regulate LRP-1 mediated endocytosis?

4. Is matrix catabolism spatially regulated by a ciliome-matrix continuum?

TBC

TBC

^ Back to Top