Dr Bing Lang
Senior Research Fellow
University of Aberdeen
Current PhD projects: Neuronal cilia, defective cell migration and brain disease. The neuronal cilia offers a unique sensory organelle that receives both mechanical and chemical signals from other cells and the environment, and transmits these signals to the nucleus to elicit a cellular response. We will analyze the effects of the perturbations on cilia assembly & function and the resulting cellular behaviour.
Schizophrenia and schizophrenia affective disorders are severe psychiatric conditions with a world-wide prevalence higher than 1%. The pathophysiology of these illnesses is not clear, although numerous susceptibility genes and environmental influences have been proposed.Disrupted-in-Schizophrenia 1 (DISC1) is one of the most compelling risk genes for schizophrenia and other major psychiatric diseases, with highly complex and diversed functions. We have generated a unique transgenic mouse line (Disc1tr mice) which successfully recaptitulate some neuropathological and behavioural phenotypes of human schizophrenia (Shen et al, 2008, J Neurosci). We are currently further phenotyping this mouse line with multi-discipline approaches. Meanwhile, we are also actively looking for novel biomarkers for this spectrum of diseases.
Neurogenesis in the brain of adult mammals occurs throughout life, and has been clearly demonstrated at two locations under normal conditions: the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus. Contribution of adult neurogenesis has been confirmed so far in learning and memory, depression and age-relating neurodegenerative diseases such as Alzheimer's disease. We are investigating this hot topic by using multiple gene-altered mouse models.