EMBO Centrosomes and spindle pole bodies


Dates: 10-13 October 2021

Centrosomes and spindle pole bodies are major microtubule organizing centres (MTOCs) of animal and yeast cells, respectively. A specialized centrosome structure also serves as template for cilia and flagella formation. These MTOCs play critical roles in cell division, cell polarity, signalling, immunity, cell motility and animal development. Centrosome abnormalities have been implicated in multiple human diseases including cancer and cilia-related syndromes. The link between aberrant centrosome function and the development of a plethora of human diseases has not only expanded the breadth and scale of the scientific community interested in centrosome biology, but also opened new avenues in centrosome research. This includes an expansion towards a molecular understanding of centrosome/cilia/spindle pole body biogenesis and function supported by the advancement of technological developments in super-resolution microscopy, proteomics, genome editing, and cryo-EM. New developments also include structural insight into centriole biogenesis, assembly of centrosomes and subcomplexes into biomolecular "condensates" through phase separation, signalling functions of centriolar satellites and the role of centrosomes in asymmetric cell division, development, inheritance and evolution.


Centrosome, centriole and spindle pole body structure
Centriole and spindle pole body duplication and function
PCM and microtubule nucleation and dynamics
Alternative or modified MTOCs
Basal bodies
Spindle pole bodies and centrosomes in development and disease

Location:  Moltkes Palace, Copenhagen, Denmark
Contact:  Jens Andersen

Updated by: Pleasantine Mill