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Dr Peter King

Department  William Harvey Research Institute
  Queen Mary University of London
Telephone  +44 (0)20 7882 6242
Email  p.j.king@qmul.ac.uk
Homepage  http://www.whri.qmul.ac.uk/staff-all/staff-research/198-king...

Research Interests

TBC

Key Publications

Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M and International FIPA Consortium (2010). Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mutat  vol. 31, (8) 950-960. 10.1002/humu.21292

King P, Paul A and Laufer E (2009). Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A  vol. 106, (50) 21185-21190. 10.1073/pnas.0909471106

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL (2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab  vol. 93, (12) 4948-4954. 10.1210/jc.2008-1744

Janes ME, Chu KME, Clark AJL and King PJ (2008). Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line. Endocrinology  vol. 149, (4) 1898-1905. 10.1210/en.2007-0949

2018

Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL and Chan LF (2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. Faseb J  10.1096/fj.201701274RR

Johnston ZC, Bellingham M, Filis P, Soffientini U, Hough D, Bhattacharya S, Simard M, Hammond GL, King P, O'Shaughnessy PJ and Fowler PA (2018). The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. Biomed Central  Bmc Med  vol. 16, (1) 23-23. 10.1186/s12916-018-1009-7

Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U, Ziegler CG, Storr HL, Druce MR, Gevers EF, Drake WM, Srirangalingam U, Conway GS, King PJ, Metherell LA, Bornstein SR and Guasti L (2018). Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. Cell Rep  vol. 22, (5) 1236-1249. 10.1016/j.celrep.2018.01.003

Read JE, Cabrera-Sharp V, Kitscha P, Cartwright JE, King PJ, Fowkes RC and de Mestre AM (2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Front Endocrinol (Lausanne)  vol. 9, 10.3389/fendo.2018.00195

2017

Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L, Taylor NF, Allen R, Marlene S, Aquilina J, Abbara A, Jaysena CN, Dhillo WS, Dunkel L, Sankilampi U and Storr HL (2017). Kisspeptin is a novel regulator of human fetal adrenocortical development and function ? a finding with important implications for the human feto-placental unit. The Journal of Clinical Endocrinology & Metabolism  10.1210/jc.2017-00763

2016

Hawkins KE, Joy S, Delhove JMKM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ, Bolanos JP, Duchen MR, Waddington SN and McKay TR (2016). NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Rep  vol. 14, (8) 1883-1891. 10.1016/j.celrep.2016.02.003

2015

Ruiz-Babot G, Hadjidemetriou I, King PJ and Guasti L (2015). New directions for the treatment of adrenal insufficiency. Front Endocrinol (Lausanne)  vol. 6, 10.3389/fendo.2015.00070

2014

Dworakowska D, Dudka D, Weitsman G, King PJ, Diaz-Cano SJ, Korbonits M, Grossman AB, Aylwin SJB, Schulte K-M, Sworczak K and Ng T (2014). Simultaneous Targeting PI3K/Akt/mTOR and MEK/RAF/ERK Pathways Results in a Synergistic Anti-Proliferative Effect in an Adrenocortical Carcinoma Model. Endocrine Reviews  vol. 35, (3)

2013

Guasti L, Cavlan D, Cogger K, Banu Z, Shakur A, Latif S and King PJ (2013). Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of ?1 integrin and ERK1/2. Endocrinology  vol. 154, (12) 4675-4684. 10.1210/en.2013-1211

Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Molecular and Cellular Endocrinology  vol. 371, (1-2) 182-188. 10.1016/j.mce.2013.01.014

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology  vol. 371, (1-2) 195-200. 10.1016/j.mce.2012.12.010

Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol  vol. 371, (1-2) 182-188. 10.1016/j.mce.2013.01.014

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol  vol. 371, (1-2) 195-200. 10.1016/j.mce.2012.12.010

Yates R, Katugampola H, Cavlan D, Cogger K, Meimaridou E, Hughes C, Metherell L, Guasti L and King P (2013). Adrenocortical development, maintenance, and disease. Curr Top Dev Biol  vol. 106, 239-312. 10.1016/B978-0-12-416021-7.00007-9

2012

Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M, Dupuis L, Loeffler J-P, King P, Mutter-Schmidt C, Petrovsky N, Stoetzel C and Dollfus H (2012). BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response. Cell Metabolism  vol. 16, (3) 363-377. 10.1016/j.cmet.2012.08.005

Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JAH, McNeilly AS and Fowkes RC (2012). Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer  vol. 19, (4) 497-508. 10.1530/ERC-12-0129

Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ, Clark AJL and Metherell LA (2012). Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet  vol. 44, (7) 740-742. 10.1038/ng.2299

Laufer E, Kesper D, Vortkamp A and King P (2012). Sonic hedgehog signaling during adrenal development. Molecular and Cellular Endocrinology  vol. 351, (1) 19-27. 10.1016/j.mce.2011.10.002

Hughes CR, Guasti L, Meimaridou E, Chuang C-H, Schimenti JC, King PJ, Costigan C, Clark AJL and Metherell LA (2012). MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans. Journal of Clinical Investigation  vol. 122, (3) 814-820. 10.1172/JCI60224

2011

Gorrigan RJ, Guasti L, King P, Clark AJ and Chan LF (2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol  vol. 46, (3) 227-232. 10.1530/JME-11-0011

Guasti L, Paul A, Laufer E and King P (2011). Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex. Mol Cell Endocrinol  vol. 336, (1-2) 117-122. 10.1016/j.mce.2010.11.010

2010

Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M and International FIPA Consortium (2010). Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mutat  vol. 31, (8) 950-960. 10.1002/humu.21292

Laufer E, King P and Paul A (2010). Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages. Endocr J  vol. 57, S309-S309.

2009

King P, Paul A and Laufer E (2009). Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A  vol. 106, (50) 21185-21190. 10.1073/pnas.0909471106

Bogdarina IG, King PJ and Clark AJL (2009). Characterization of the angiotensin (AT1b) receptor promoter and its regulation by glucocorticoids. J Mol Endocrinol  vol. 43, (2) 73-80. 10.1677/JME-09-0036

Garcia EA, King P, Sidhu K, Ohgusu H, Walley A, Lecoeur C, Gueorguiev M, Khalaf S, Davies D, Grossman AB, Kojima M, Petersenn S, Froguel P and Korbonits M (2009). The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes. Eur J Endocrinol  vol. 161, (2) 307-315. 10.1530/EJE-09-0122

2008

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL (2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab  vol. 93, (12) 4948-4954. 10.1210/jc.2008-1744

King PJ, Guasti L and Laufer E (2008). Hedgehog signalling in endocrine development and disease. J Endocrinol  vol. 198, (3) 439-450. 10.1677/JOE-08-0161

Janes ME, Chu KME, Clark AJL and King PJ (2008). Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line. Endocrinology  vol. 149, (4) 1898-1905. 10.1210/en.2007-0949

2007

Doufexis M, Storr HL, King PJ and Clark AJL (2007). Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. Faseb J  vol. 21, (14) 4095-4100. 10.1096/fj.06-7927com

Hu L, Monteiro A, Johnston H, King P and O'Shaughnessy PJ (2007). Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Reproduction  vol. 134, (4) 585-591. 10.1530/REP-07-0133

Johnston H, King PJ and O'Shaughnessy PJ (2007). Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis. Reproduction  vol. 133, (6) 1181-1187. 10.1530/REP-06-0359

Bogdarina I, Welham S, King PJ, Burns SP and Clark AJL (2007). Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res  vol. 100, (4) 520-526. 10.1161/01.RES.0000258855.60637.58

2006

Noon LA, Clark AJL, O'Shaughnessy PJ and King PJ (2006). A CCAAT/enhancer-binding protein site at -87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis. Endocrinology  vol. 147, (12) 6019-6026. 10.1210/en.2006-0867

Noon LA, Bakmanidis A, Clark AJL, O'Shaughnessy PJ and King PJ (2006). Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis. J Mol Endocrinol  vol. 37, (3) 415-420. 10.1677/jme.1.02023

White NR, Mulligan P, King PJ and Sanderson IR (2006). Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells. J Pediatr Gastroenterol Nutr  vol. 42, (2) 134-141. 10.1097/01.mpg.0000189345.31010.89

2004

Noon LA, Clark AJL and King PJ (2004). A peroxisome proliferator-response element in the murine mc2-r promoter regulates its transcriptional activation during differentiation of 3T3-L1 adipocytes. J Biol Chem  vol. 279, (22) 22803-22808. 10.1074/jbc.M401861200

King P, CLARK AJL and Noon LA (2004). A Peroxisome Proliferator-response Element in the Murine mc2-r Promoter Regulates Its Transcriptional Activation during Differentiation of 3T3-L1 Adipocytes. Journal of Biological Chemistry  vol. 279, (22) 22803-22808. 10.1074/jbc.M401861200

Swords FM, Noon LA, King PJ and Clark AJL (2004). Constitutive activation of the human ACTH receptor resulting from a synergistic interaction between two naturally occurring missense mutations in the MC2R gene. Mol Cell Endocrinol  vol. 213, (2) 149-154. 10.1016/j.mce.2003.10.052

2003

Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJB, King P, Ingraham HA and Burrin JM (2003). Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes. Mol Endocrinol  vol. 17, (11) 2177-2188. 10.1210/me.2002-0393

Fowkes RC, Sidhu KK, Sosabowski JK, King P and Burrin JM (2003). Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription. J Mol Endocrinol  vol. 31, (2) 263-278. 10.1677/jme.0.0310263

2002

Swords FM, Baig A, Malchoff DM, Malchoff CD, Thorner MO, King PJ, Hunyady L and Clark AJL (2002). Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity. Mol Endocrinol  vol. 16, (12) 2746-2753. 10.1210/me.2002-0099

Kosti O, King PJ and Hinson JP (2002). Tumour-derived human adrenocortical cells express beta-adrenergic receptors: steroidogenic effects of beta-adrenergic input. Endocr Res  vol. 28, (4) 363-367. 10.1081/ERC-120016810

Baig AH, Swords FM, Szaszák M, King PJ, Hunyady L and Clark AJL (2002). Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Endocr Res  vol. 28, (4) 281-289. 10.1081/ERC-120016798

Fowkes RC, King P and Burrin JM (2002). Regulation of human glycoprotein hormone alpha-subunit gene transcription in L beta T2 gonadotropes by protein kinase C and extracellular signal-regulated kinase 1/2. Biol Reprod  vol. 67, (3) 725-734. 10.1095/biolreprod67.3.725

Noon LA, Franklin JM, King PJ, Goulding NJ, Hunyady L and Clark AJL (2002). Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor. J Endocrinol  vol. 174, (1) 17-25. 10.1677/joe.0.1740017

2001

Baig AH, Swords FM, Noon LA, King PJ, Hunyady L and Clark AJ (2001). Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes. J Biol Chem  vol. 276, (48) 44792-44797. 10.1074/jbc.M108572200

Newell-Price J, King P and Clark AJ (2001). The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. Mol Endocrinol  vol. 15, (2) 338-348. 10.1210/mend.15.2.0599

KING PJ, Clark AJL and Newell-Price J (2001). Methylation of a tissue-specific CpG island in normal non-expressing human tissue. Mol Endo  vol. 15, 338-348.

TBC

TBC

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